Molecular Biology

Andrew Franklin's Activation-Induced Deaminase: On the Targeting Mechanism of PDF

By Andrew Franklin

During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a procedure known as affinity maturation. a bunch produces antibodies with successively higher affinities with repeated publicity to an identical antigen, that's the primary in which so much vaccines work.
Affinity maturation depends on hypermutation, an iterative strategy of mutation at antibody-encoding genes, via optimistic collection of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation can result in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant step forward got here in 2000 with the invention that activation-induced deaminase (AID) is basically required for hypermutation. This was once in 2002 by way of facts that relief at once edits the DNA that encodes an antibody in an activated B mobilephone. a lot has seeing that been learnt concerning the biochemistry and rules of reduction, however the mechanism during which it truly is recruited in particular to antibody-encoding genes continues to be enigmatic. figuring out this recruitment is clinically major simply because off-target relief job at oncogenes may end up in chromosomal translocations and tumorigenesis.
This e-book summarizes the examine on reduction within the context of its significant position within the affinity maturation of B cells.

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Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin

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